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	Provedor de dados BJID (1) Autor Albério,Carlos Augusto Abreu (1) Lucena,Stefania de Medeiros Araujo (1) Pinto,Ana Carla Godinho (1) Uchoa,Breno Kristoffer Beleza (1) Vieira,José Luiz Fernandes (1) Palavra-chave Infectious disease (1) Rifampicin (1) Tuberculosis (1) Tipo do documento Info:eu-repo/semantics/other (1) Ano 2019 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Concentrations of rifampicin in pre-dose samples in patients with pulmonary tuberculosis BJID Uchoa,Breno Kristoffer Beleza; Albério,Carlos Augusto Abreu; Pinto,Ana Carla Godinho; Lucena,Stefania de Medeiros Araujo; Vieira,José Luiz Fernandes. ABSTRACT Rifampicin is used in both phases of treatment for tuberculosis. In chronic use, the short half-life and the self-induction of metabolism can decrease the levels of the drug below the minimal inhibitory concentration. The aim of the study was to investigate whether plasma concentrations of rifampicin are sustained above 0.5 µg/mL in patients with tuberculosis using 600 mg/day. Rifampicin was measured in plasma by high-performance liquid chromatography and a sputum smear microscopy was performed in all days of the study. A total of 44 male patients completed the study. On days 31, 61 and 91, the mean plasma concentrations of rifampicin were 0.6 (0.5) µg/mL, 0.55 (0.5) µg/mL and 0.46 (0.4) µg/mL. There was a high variation of rifampicin levels... Tipo: Info:eu-repo/semantics/other Palavras-chave: Infectious disease; Tuberculosis; Rifampicin. Ano: 2019 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702019000200130 Registros recuperados: 1 Primeira ... 1 ... Última

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